A thorough meta-analysis suggests that vitamin D treatment may reduce depressive symptoms in persons with depression. The meta-analysis, which was carried out by an international team of scientists, includes numerous research studies from various countries. The journal Critical Reviews in Food Science and Nutrition has published it.
The global illness burden is significantly increased by depressive symptoms. Current antidepressants frequently lack the therapeutic efficacy needed to properly treat depression. This is why researchers have looked for additional strategies to treat the signs and symptoms of depression, such as through nutritional studies.
Functions of the central nervous system are hypothesized to be regulated by vitamin D. Depression has been linked to disturbances in these processes. Additionally, vitamin D insufficiency and depression symptoms have been linked in cross-sectional research. But prior meta-analyses on the connection between vitamin D supplementation and depression have come up empty. Results from various studies are integrated and statistically assessed in a meta-analysis.
The most comprehensive meta-analysis on the relationship between vitamin D supplementation and depression has just been published. In actuality, it contained findings from 41 international studies. These studies used randomized placebo-controlled trials in various demographics to examine the effectiveness of vitamin D in reducing depression symptoms in adults. The research covered those conducted on depressed patients, the general public, and individuals with different physical conditions.
The meta-findings analysis demonstrates that supplementing with vitamin D reduces depressive symptoms in depressed individuals more effectively than a placebo. The amounts of vitamin D utilized varied greatly, but the common vitamin D dosage was 50–100 micrograms (2,000–4,000 IU) daily.
Due to the heterogeneity of the populations studied and the risk of bias associated with a large number of studies, says lead author and doctoral researcher Tuomas Mikola of the Institute of Clinical Medicine at the University of Eastern Finland, "despite the broad scope of this meta-analysis, the certainty of evidence remains low." Part of Mikola's Ph.D. dissertation is the meta-analysis.
These results will stimulate new, high-quality clinical studies in depressed individuals in order to clarify the potential function of vitamin D supplementation in the management of depression, says Mikola.
The authors of "The Effect of Vitamin D Supplementation on Depressive Symptoms in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials," Tuomas Mikola, Wolfgang Marx, Melissa M. Lane, Meghan Hockey, Amy Loughman, Sanna Rajapolvi, Tetyana Rocks, Adrienne O'Neil, David Mischoulon, Minna Valkonen-Korhonen, Soili M. Lehto,
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